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cytosine - guanine necklace | gold vermeil meta-catalog Because RNA biology is thecytosine guanine necklace 18k gold vermeil Of the two DNA base pairs, the cytosine guanine pair is the stronger one. Three hydrogen bonds instead of two, which makes GC rich regions thermally more stable and gives them distinct roles in genome architecture. Cytosine is also where DNA methylation lives, the central currency of epigenetic regulation. The Chemistry of the C G Base Pair The cytosine guanine pair bonds via three hydrogen bridges (adenine